Premium
Noninvasive Imaging of Dendrimer‐Type N‐Glycan Clusters: In Vivo Dynamics Dependence on Oligosaccharide Structure
Author(s) -
Tanaka Katsunori,
Siwu Eric R. O.,
Minami Kaori,
Hasegawa Koki,
Nozaki Satoshi,
Kanayama Yousuke,
Koyama Koichi,
Chen Weihsu C.,
Paulson James C.,
Watanabe Yasuyoshi,
Fukase Koichi
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201000892
Subject(s) - glycan , dendrimer , in vivo , glycosyl , chemistry , biophysics , oligosaccharide , molecular dynamics , stereochemistry , biochemistry , glycoprotein , biology , computational chemistry , microbiology and biotechnology
Body image : Self‐activating Huisgen 1,3‐dipolar cycloaddition and 6π azaelectrocyclization of lysine‐based dendrimers (see picture) enable the in vivo dynamics and organ‐specific accumulation of N‐glycans to be visualized. The sugar structure and glycosyl bond linkages of N‐glycans control the whole‐body trafficking of the clusters in nude mice and a cancer model.