Premium
Quantitative Measurement of Nano‐/Microparticle Endocytosis by Cell Mass Spectrometry
Author(s) -
Lin HuanChang,
Lin HsinHung,
Kao CaiYu,
Yu Alice L.,
Peng WenPing,
Chen ChungHsuan
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201000891
Subject(s) - mass spectrometry , microparticle , endocytosis , inductively coupled plasma mass spectrometry , chemistry , colloidal gold , nanoparticle , polystyrene , nano , chromatography , analytical chemistry (journal) , nanotechnology , materials science , cell , chemical engineering , polymer , biochemistry , organic chemistry , engineering , composite material
All present and accounted for? Cell mass spectrometry was used to determine the quantity of both gold and polystyrene nano‐/microparticles taken up into cells (see picture). The uptake amounts measured for gold nanoparticles were similar to those determined by inductively coupled plasma mass spectrometry, a technique which can not be used to measure the cellular uptake of nonmetal particles.