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Enantioselective Synthesis of (−)‐Englerins A and B
Author(s) -
Molawi Kian,
Delpont Nicolas,
Echavarren Antonio M.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201000890
Subject(s) - stereocenter , enantioselective synthesis , domino , stereoselectivity , alkene , enantiomer , alkyne , stereochemistry , chemistry , computer science , organic chemistry , catalysis
All that glitters is gold : The total synthesis of the natural enantiomers of englerins A and B has been completed using a gold‐catalyzed stereoselective domino alkyne/alkene/carbonyl cyclization of an enyne with an unprotected alcohol group at a stereogenic allylic position (see scheme; TES=triethylsilyl).
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