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Asymmetric, Protecting‐Group‐Free Total Synthesis of (−)‐Englerin A
Author(s) -
Zhou Qianghui,
Chen Xiaofei,
Ma Dawei
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201000888
Subject(s) - key (lock) , computer science , sequence (biology) , group (periodic table) , natural (archaeology) , total synthesis , information retrieval , stereochemistry , computer security , history , chemistry , organic chemistry , biochemistry , archaeology
The golden touch : Total synthesis of natural (−)‐englerin A from ( R )‐citronellal has been achieved using a gold‐catalyzed cyclization as the key step (see scheme). No protecting‐group manipulations were required in the synthetic sequence.