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Cover Picture: 1 H DOSY Spectra of Ligands for Highly Enantioselective Reactions—A Fast and Simple NMR Method to Optimize Catalytic Reaction Conditions (Angew. Chem. Int. Ed. 15/2010)
Author(s) -
Schober Katrin,
Hartmann Evelyn,
Zhang Hongxia,
Gschwind Ruth M.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201000866
Subject(s) - catalysis , enantioselective synthesis , chemistry , cover (algebra) , reaction conditions , spectral line , combinatorial chemistry , simple (philosophy) , transition metal , organic chemistry , physics , mechanical engineering , philosophy , epistemology , astronomy , engineering
A fast and easy DOSY screening of ligands that affords high enantioselectivities in catalysis allows the aggregation trends of their transition‐metal complexes to be predicted. In their Communication on page 2794 ff., R. Gschwind and co‐workers present the first aggregation study of selected phosphoramidites and their complexes. This method is useful for catalyst optimization as no knowledge of the complex structure is necessary and the temperature range applicable to the desired catalytic reaction can be quickly determined.