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Reductive Dehydroxylation of Allyl Alcohols by IspH Protein
Author(s) -
Gräwert Tobias,
Span Ingrid,
Bacher Adelbert,
Groll Michael
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201000833
Subject(s) - chemistry , treasure , allyl alcohol , biosynthesis , alcohol , biochemistry , stereochemistry , combinatorial chemistry , catalysis , enzyme , philosophy , theology
The biosynthesis of natural products is a treasure trove of unusual reaction mechanisms. This Minireview summarizes recent work on the structure and mechanism of IspH protein, which catalyzes the reductive dehydroxylation of an allyl alcohol in a biosynthetic pathway leading to isoprenoid precursors.