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Enantioselective Palladium‐Catalyzed Direct Alkylation and Olefination Reaction of Simple Arenes
Author(s) -
Peng Hong Mei,
Dai LiXin,
You ShuLi
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201000799
Subject(s) - enantioselective synthesis , palladium , alkylation , catalysis , chemistry , enantiomer , combinatorial chemistry , enantiomeric excess , organic chemistry , simple (philosophy) , philosophy , epistemology
Easy as pie : Simple amino acid derivatives and phosphoramidites assist palladium in the enantioselective direct alkylation and olefination of simple arenes (see scheme; Boc= tert ‐butoxycarbonyl, Tf=trifluoromethanesulfonyl). Under mild reaction conditions, a practical level of enantiomeric excess was obtained.