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Rhodium‐Catalyzed Cyclopropenation of Alkynes: Synthesis of Trifluoromethyl‐Substituted Cyclopropenes
Author(s) -
Morandi Bill,
Carreira Erick M.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201000787
Subject(s) - trifluoromethyl , rhodium , domino , catalysis , chemistry , combinatorial chemistry , hydrochloride , organic chemistry , medicinal chemistry , alkyl
Make it strained and fluorinated! A rhodium‐catalyzed domino diazotization/cyclopropenation reaction involving trifluoroethylamine hydrochloride and alkynes has been developed for the synthesis of trifluoromethyl cyclopropenes that can be easily functionalized to afford useful CF 3 ‐containing building blocks for drug discovery.
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