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On the Reach of Chemical Synthesis: Creation of a Mini‐Pipeline from an Academic Laboratory
Author(s) -
Wilson Rebecca M.,
Danishefsky Samuel J.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201000775
Subject(s) - pharmaceutics , pipeline (software) , identification (biology) , computer science , recall , data science , computational biology , chemistry , medicine , psychology , biology , pharmacology , cognitive psychology , programming language , botany
In this retrospective, we recall some select cases of synergy between very challenging chemical synthesis and the identification of promising new candidates for pharmaceutics development. The progression from targets, often referred to as small molecules, to those of a size commonly associated with biologics (including glycoproteins) is also charted.