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Cover Picture: Enantioselective Kita Oxidative Spirolactonization Catalyzed by In Situ Generated Chiral Hypervalent Iodine(III) Species (Angew. Chem. Int. Ed. 12/2010)
Author(s) -
Uyanik Muhammet,
Yasui Takeshi,
Ishihara Kazuaki
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201000768
Subject(s) - hypervalent molecule , enantioselective synthesis , catalysis , iodine , chemistry , hydrogen bond , cover (algebra) , organocatalysis , combinatorial chemistry , in situ , oxidative phosphorylation , medicinal chemistry , organic chemistry , molecule , biochemistry , mechanical engineering , engineering
Conformationally flexible C 2 ‐symmetric chiral iodosylarene, which has been rationally designed based on secondary n –σ* or hydrogen‐bonding interactions, is a highly effective catalyst for the Kita oxidative spirolactonization. As described by K. Ishihara and co‐workers in their Communication on page 2175 ff., this catalysis provides the highest enantioselectivity (up to 92 % ee ) among previous chiral hypervalent iodine‐catalyzed reactions.