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Direct, One‐pot Sequential Reductive Alkylation of Lactams/Amides with Grignard and Organolithium Reagents through Lactam/Amide Activation
Author(s) -
Xiao KaiJiong,
Luo JieMin,
Ye KeYin,
Wang Yu,
Huang PeiQiang
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201000652
Subject(s) - reagent , amide , alkylation , combinatorial chemistry , lactam , grignard reagent , chemistry , sequence (biology) , stereochemistry , computer science , organic chemistry , biochemistry , catalysis
Be dazzled by the sequence : The first efficient and general one‐pot method for the reductive bisalkylation of lactams/amides with Grignard and organolithium reagents has been developed (see scheme; DTBMP=2,6‐di‐ tert ‐butyl‐4‐methylpyridine, Tf=trifluoromethanesulfonyl).
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