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A Concise Total Synthesis of (+)‐Neopeltolide
Author(s) -
Fuwa Haruhiko,
Saito Asami,
Sasaki Makoto
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201000624
Subject(s) - olefin metathesis , total synthesis , computer science , information retrieval , world wide web , metathesis , library science , chemistry , stereochemistry , organic chemistry , polymerization , polymer
Short and sweet : The highly potent antiproliferative marine macrolide (+)‐neopeltolide has been synthesized based on the strategic application of olefin metathesis reactions. The total synthesis proceeded in only 13 steps from commercially available starting materials, and represents the shortest synthesis of (+)‐neopeltolide reported to date.