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The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain
Author(s) -
Clark Richard J.,
Jensen Jonas,
Nevin Simon T.,
Callaghan Brid P.,
Adams David J.,
Craik David J.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201000620
Subject(s) - neuropathic pain , conotoxin , disadvantage , orally active , medicine , psychology , computer science , pharmacology , artificial intelligence , biology , ecology , oral administration , venom
From killers to curers : Peptides from cone snail venoms are potential therapeutic agents for the treatment of neuropathic pain. Unfortunately, these peptides suffer from the disadvantage of short biological half‐lives and poor activity when taken orally. A new orally active conotoxin was developed to solve these problems.