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Unraveling the Biosynthesis of Nature’s Fastest Hydrogenase
Author(s) -
Rauchfuss Thomas B.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201000597
Subject(s) - hydrogenase , cyanide , biosynthesis , chemistry , active site , combinatorial chemistry , enzyme , biochemistry , organic chemistry
Take two cyanides and report to work! Cyanide is an essential ingredient of the [FeFe]‐hydrogenases. Recent studies have revealed how nature makes these cyanide ligands coordinated to the diiron core of the active site (see structure). Rapidly unfolding research on the maturation process is revealing new dimensions of biosynthesis. The transformations discovered may lead to the development of useful organometallic reactions.