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A P,N‐Ligand for Palladium‐Catalyzed Ammonia Arylation: Coupling of Deactivated Aryl Chlorides, Chemoselective Arylations, and Room Temperature Reactions
Author(s) -
Lundgren Rylan J.,
Peters Brendan D.,
Alsabeh Pamela G.,
Stradiotto Mark
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201000526
Subject(s) - chemoselectivity , aryl , palladium , ammonia , ligand (biochemistry) , chemistry , catalysis , chloride , combinatorial chemistry , organic chemistry , medicinal chemistry , receptor , biochemistry , alkyl
Amazing ammonia : A new air‐stable P,N‐ligand (Mor‐DalPhos) is reported that enables the palladium‐catalyzed cross‐coupling of ammonia to a variety of aryl chloride and aryl tosylate substrates with high chemoselectivity and, for the first time, at room temperature (see scheme; Ad=adamantyl, Ts= para ‐toluenesulfonyl).