A P,N‐Ligand for Palladium‐Catalyzed Ammonia Arylation: Coupling of Deactivated Aryl Chlorides, Chemoselective Arylations, and Room Temperature Reactions | Zendy

Lundgren Rylan J. | Zendy; Peters Brendan D. | Zendy; Alsabeh Pamela G. | Zendy; Stradiotto Mark | Zendy

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A P,N‐Ligand for Palladium‐Catalyzed Ammonia Arylation: Coupling of Deactivated Aryl Chlorides, Chemoselective Arylations, and Room Temperature Reactions

Author(s) -

Lundgren Rylan J.,

Peters Brendan D.,

Alsabeh Pamela G.,

Stradiotto Mark

Publication year - 2010

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201000526

Subject(s) - chemoselectivity , aryl , palladium , ammonia , ligand (biochemistry) , chemistry , catalysis , chloride , combinatorial chemistry , organic chemistry , medicinal chemistry , receptor , biochemistry , alkyl

Amazing ammonia : A new air‐stable P,N‐ligand (Mor‐DalPhos) is reported that enables the palladium‐catalyzed cross‐coupling of ammonia to a variety of aryl chloride and aryl tosylate substrates with high chemoselectivity and, for the first time, at room temperature (see scheme; Ad=adamantyl, Ts= para ‐toluenesulfonyl).

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