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Exploiting the Regioselectivity of Baeyer–Villiger Monooxygenases for the Formation of β‐Amino Acids and β‐Amino Alcohols
Author(s) -
Rehdorf Jessica,
Mihovilovic Marko D.,
Bornscheuer Uwe T.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201000511
Subject(s) - regioselectivity , monooxygenase , amino acid , alcohol , scheme (mathematics) , leucine , computer science , chemistry , stereochemistry , organic chemistry , biochemistry , catalysis , mathematics , enzyme , cytochrome p450 , mathematical analysis
To the left or to the right? The regioselective insertion of oxygen in Baeyer–Villiger monooxygenase (BVMO) catalyzed oxidations not only affords the expected protected β‐amino alcohol, but can also be used to provide access to β‐amino acids as exemplified for β‐leucine (see scheme; PG=protecting group).