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Chiral Tetrafluorobenzobarrelenes as Effective Ligands for Rhodium‐Catalyzed Asymmetric 1,4‐Addition of Arylboroxines to β,β‐Disubstituted α,β‐Unsaturated Ketones
Author(s) -
Shintani Ryo,
Takeda Momotaro,
Nishimura Takahiro,
Hayashi Tamio
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201000467
Subject(s) - stereocenter , rhodium , enantiomer , chemistry , catalysis , ligand (biochemistry) , combinatorial chemistry , organic chemistry , enantioselective synthesis , stereochemistry , biochemistry , receptor
Lock, Stock and Two Smoking Barrelenes : The rhodium‐catalyzed 1,4‐addition of readily available arylboronic acid anhydrides to simple β,β‐disubstituted α,β‐unsaturated ketones creates quaternary carbon stereocenters with high enantiomeric excesses using a chiral tetrafluorobenzobarrelene ligand.