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Osmium‐Catalyzed 7‐ endo Heterocyclization of Aromatic Alkynols into Benzoxepines
Author(s) -
VarelaFernández Alejandro,
GarcíaYebra Cristina,
Varela Jesús A.,
Esteruelas Miguel A.,
Saá Carlos
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201000455
Subject(s) - osmium , chemistry , regioselectivity , catalysis , key (lock) , computer science , combinatorial chemistry , hydride , organic chemistry , ruthenium , metal , operating system
The wizard of Os : Regioselective osmium‐catalyzed 7‐ endo heterocyclization of aromatic alkynols affords benzoxepines in good yields. The proposed catalytic cycle involves the key formation of osmium–vinylidene complexes via an alkynyl‐hydride–osmium(IV) complex from the starting alkynol.