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Asymmetric [3+2] Cycloadditions of Allenoates and Dual Activated Olefins Catalyzed by Simple Bifunctional N ‐Acyl Aminophosphines
Author(s) -
Xiao Hua,
Chai Zhuo,
Zheng ChangWu,
Yang YingQuan,
Liu Wen,
Zhang JunKang,
Zhao Gang
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201000446
Subject(s) - bifunctional , regioselectivity , cycloaddition , chemistry , simple (philosophy) , catalysis , dual (grammatical number) , combinatorial chemistry , organic chemistry , computer science , philosophy , linguistics , epistemology
Bifunctional catalyst : Simple bifunctional N ‐Acyl aminophosphines such as 1 were developed to catalyze the first asymmetric [3+2] cycloaddition between allenoates and dual activated olefins. The cycloaddition reactions afford multifunctional chiral cyclopentenes with exclusive regioselectivity, and good to excellent enantioselectivity and yields.