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Gold‐Catalyzed Cycloisomerization Reactions of 2‐Tosylaminophenylprop‐1‐yn‐3‐ols as a Versatile Approach for Indole Synthesis
Author(s) -
Kothandaraman Prasath,
Rao Weidong,
Foo Shi Jia,
Chan Philip Wai Hong
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201000341
Subject(s) - cycloisomerization , indole test , catalysis , chemistry , combinatorial chemistry , transformation (genetics) , reaction conditions , medicinal chemistry , organic chemistry , biochemistry , gene
A great combination : A putative indolyl‐substituted vinyl gold species generated in situ from AuCl/AgOTf catalyzed the title transformation. Under these reaction conditions, indenyl‐fused and 2,3‐disubstituted indole derivatives were produced in good to excellent yields of up to 94 % (see scheme).