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An Engineered Metalloprotein as a Functional and Structural Bioinorganic Model System
Author(s) -
Ueno Takafumi
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201000337
Subject(s) - bioinorganic chemistry , metalloprotein , chemistry , yield (engineering) , rational design , nanotechnology , materials science , stereochemistry , enzyme , biochemistry , metallurgy
How best to mimic a protein : Rational design based on the use of a metalloprotein as the molecular scaffold led to a structural (see picture) and functional model of a metalloenzyme that is difficult to obtain in high yield and for which no crystal structure has been determined. This approach will be useful for the preparation of models of sophisticated functional metal centers that are difficult to prepare by chemical synthesis.