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A Left‐Handed Solution to Peptide Inhibition of the p53–MDM2 Interaction
Author(s) -
Liu Min,
Pazgier Marzena,
Li Changqing,
Yuan Weirong,
Li Chong,
Lu Wuyuan
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201000329
Subject(s) - mdm2 , peptide , throwing , phage display , suppressor , protease , cancer research , computational biology , chemistry , computer science , biology , biochemistry , physics , apoptosis , gene , classical mechanics , enzyme
Throwing tumors a left‐hook punch : The oncoprotein MDM2 negatively regulates the activity and stability of the tumor suppressor protein p53, and is an important molecular target for anticancer therapy. Mirror‐image phage display identified a high‐affinity D ‐peptide ligand of MDM2 (see structure) that could be developed into a potent and protease‐resistant p53 activator with potential antitumor activity.