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Catalytic Intramolecular Ketone Hydroacylation: Enantioselective Synthesis of Phthalides
Author(s) -
Willis Michael C.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201000159
Subject(s) - hydroacylation , intramolecular force , enantioselective synthesis , ketone , chemistry , catalysis , ligand (biochemistry) , rhodium , diene , combinatorial chemistry , organic chemistry , medicinal chemistry , biochemistry , natural rubber , receptor
Controlling carbonyl groups : Identification of the correct ligand/counterion combination was essential to allow the efficient and selective rhodium‐catalyzed conversion of a series of ketobenzaldehydes into the corresponding phthalides using the title reaction (see scheme; cod=cycloocta‐l,5‐diene).