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Rhodamines NN: A Novel Class of Caged Fluorescent Dyes
Author(s) -
Belov Vladimir N.,
Wurm Christian A.,
Boyarskiy Vadim P.,
Jakobs Stefan,
Hell Stefan W.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201000150
Subject(s) - diazomethane , fluorescence , diazo , chemistry , photochemistry , combinatorial chemistry , organic chemistry , optics , physics
A bright future : The reaction of diazomethane with acid chlorides obtained from N , N , N ′, N ′‐tetraalkylrhodamines affords 2‐diazo‐2,3‐dihydro‐1 H ‐indenespiro[1,9′]‐9 H ‐xanthen‐3‐ones—a novel class of caged rhodamines. These dyes allow new imaging procedures based on the step‐wise activation and detection of several fluorescent markers (see picture).