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Bimodal MR–PET Agent for Quantitative pH Imaging
Author(s) -
Frullano Luca,
Catana Ciprian,
Benner Thomas,
Sherry A. Dean,
Caravan Peter
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201000075
Subject(s) - imaging agent , chemistry , pet imaging , positron emission tomography , nuclear medicine , nuclear magnetic resonance , medicine , physics , biology , microbiology and biotechnology , in vivo
Two unknowns : The relaxivity of activatable magnetic resonance (MR) contrast agents depends on environmental factors, such as the pH value or enzymatic activity, but the MR signal depends on relaxivity and agent concentration. Simultaneous positron emission tomography (PET) and MR imaging (MRI) with the bimodal, pH‐responsive MR–PET agent shown enabled the direct determination of concentration and T 1 , and hence the pH value.