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Building Addressable Libraries as Platforms for Biological Assays by an Electrochemical Method
Author(s) -
Yoshida Junichi,
Nagaki Aiichiro
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201000046
Subject(s) - electrochemistry , combinatorial chemistry , microelectrode , agarose , nanotechnology , electrode , copolymer , chemistry , molecule , coating , materials science , organic chemistry , polymer , chromatography
A well‐stocked toolbox is available for the site‐selective arrangement of molecules on microelectrode arrays to form addressable libraries thanks to a combination of electrochemistry with a variety of organometallic reactions, such as the Suzuki reaction (see scheme; TBAB=tetrabutylammonium bromide). A diblock copolymer formed an advantageous electrode coating in place of conventional agarose and sucrose.