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Cover Picture: Microscale Control of Stiffness in a Cell‐Adhesive Substrate Using Microfluidics‐Based Lithography (Angew. Chem. Int. Ed. 39/2009)
Author(s) -
Cheung Yuk Kee,
Azeloglu Evren U.,
Shiovitz David A.,
Costa Kevin D.,
Seliktar Dror,
Sia Samuel K.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200990204
Subject(s) - microscale chemistry , microfluidics , materials science , nanotechnology , adhesive , lithography , ethylene glycol , substrate (aquarium) , polydimethylsiloxane , layer (electronics) , optoelectronics , chemical engineering , oceanography , mathematics education , mathematics , geology , engineering
Microfluidics‐based lithography is used to pattern a cell‐adhesive hydrogel substrate with microscale variations in stiffness that can mimic those of native tissues. As shown by S. K. Sia and co‐workers in their Communication on page 7188 ff. , the micropatterns are fabricated by delivering PEG‐fibrinogen and various amounts of poly(ethylene glycol) diacrylate (PEGDA) into a microfluidic chamber. Cells are then placed on top of the micropatterns to study their interactions with the extracellular matrix.