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Cover Picture: An Enantiomerically Pure Alleno‐Acetylenic Macrocycle: Synthesis and Rationalization of Its Outstanding Chiroptical Response (Angew. Chem. Int. Ed. 30/2009)
Author(s) -
AlonsoGómez José Lorenzo,
RiveraFuentes Pablo,
Harada Nobuyuki,
Berova Nina,
Diederich François
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200990154
Subject(s) - enantiopure drug , circular dichroism , rationalization (economics) , chemistry , optically active , stereochemistry , crystallography , enantioselective synthesis , organic chemistry , catalysis , philosophy , epistemology
Enantiopure, Shape‐Persistent alleno‐acetylenic macrocycles are prepared from optically pure 1,3‐diethynylallene building blocks, as F. Diederich et al. report in their Communication on page 5545 ff. These macrocycles with their crown geometry and chiral C 28 backbone are not only aesthetically pleasing, they also display unusually intense Cotton effects in their circular dichroism spectra, which arise from the unique interplay of the shape‐persistent geometry and electronic properties.