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Inside Cover: Matrix‐Free Formation of Gas‐Phase Biomolecular Ions by Soft Cluster‐Induced Desorption (Angew. Chem. Int. Ed. 23/2009)
Author(s) -
Gebhardt Christoph. R.,
Tomsic Anna,
Schröder Hartmut,
Dürr Michael,
Kompa Karl L.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200990118
Subject(s) - desorption , biomolecule , ion , cluster (spacecraft) , phase (matter) , matrix (chemical analysis) , adsorption , gas phase , cover (algebra) , mass spectrometry , chemical physics , chemistry , materials science , analytical chemistry (journal) , nanotechnology , chromatography , organic chemistry , computer science , programming language , mechanical engineering , engineering
Abstract Mass spectrometry of biomolecules has developed into a key technology in bioanalytics. As described by C. R. Gebhardt, M. Dürr et al. in their Communication on page 4162 ff., surface collisions of neutral molecular clusters can be used for soft formation of the required gas‐phase biomolecular ions. Upon impact on a surface, the clusters provide the energy for desorption of the adsorbed biomolecules and serve as a transient matrix. Subsequent evaporative cooling prevents shattering and finally leads to an isolated biomolecular ion in the gas phase.