Premium
Inside Cover: Synthesis and Biological Activity of Argiotoxin 636 and Analogues: Selective Antagonists for Ionotropic Glutamate Receptors (Angew. Chem. Int. Ed. 17/2009)
Author(s) -
Nelson Jared K.,
Frølund Sidsel U.,
Tikhonov Dennis B.,
Kristensen Anders S.,
Strømgaard Kristian
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200990085
Subject(s) - ionotropic effect , glutamate receptor , receptor , chemistry , kainate receptor , stereochemistry , pharmacology , biology , biochemistry , ampa receptor
Spiders of the genus Argiope , such as Argiope lobata , contain polyamine toxins that are potent but nonselective blockers of glutamate receptors. However, by very subtle modifications of the structure of native toxins, it is possible to obtain selectivity for subtypes of these receptors, as described by K. Strømgaard and co‐workers in their Communication on page 3087 ff.