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Inside Cover: A Synthetic Lectin for O‐Linked β‐ N ‐Acetylglucosamine (Angew. Chem. Int. Ed. 10/2009)
Author(s) -
Ferrand Yann,
Klein Emmanuel,
Barwell Nicholas P.,
Crump Matthew P.,
JiménezBarbero Jesus,
Vicent Cristina,
Boons GeertJan,
Ingale Sampat,
Davis Anthony P.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200990042
Subject(s) - lectin , receptor , affinities , chemistry , cover (algebra) , int , carbohydrate , stereochemistry , n acetylglucosamine , glycoprotein , biochemistry , combinatorial chemistry , computer science , engineering , mechanical engineering , enzyme , operating system
Carbohydrates are slippery customers in water. Camouflaged by solvent‐mimicking hydroxy groups, they make challenging targets, even for natural receptors. In their Communication on page 1775 ff., A. P. Davis and co‐workers describe a synthetic receptor that is remarkably effective for the important β‐ N ‐acetylglucosaminyl (β‐GlcNAC) unit. The affinities of the receptor are good and its selectivities are excellent, even by the standards of natural carbohydrate‐binding proteins.