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Direct Application of Phenolic Salts to Nickel‐Catalyzed Cross‐Coupling Reactions with Aryl Grignard Reagents
Author(s) -
Yu DaGang,
Li BiJie,
Zheng ShuFang,
Guan BingTao,
Wang BiQing,
Shi ZhangJie
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200907359
Subject(s) - aryl , nickel , atom economy , halide , electrophile , reagent , catalysis , coupling reaction , coupling (piping) , chemistry , phenol , combinatorial chemistry , atom (system on chip) , organic chemistry , materials science , metallurgy , computer science , alkyl , embedded system
You're nickel'd pal! The first successful coupling reaction with the direct application of naphtholates as electrophiles (see scheme, X=halide) improves both the step economy and atom economy of cross‐coupling reactions whilst decreasing the cost of preparing complex scaffolds from readily available phenol derivatives.