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Surface‐Bound Microenclosures for Biomolecules
Author(s) -
Lin Laiyi,
Beyer Sebastian,
Wohland Thorsten,
Trau Dieter,
Lubrich Daniel
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200907321
Subject(s) - biomolecule , nucleic acid , chemistry , computer science , dna , nanotechnology , materials science , biochemistry
It's a trap! A simple process based on reverse‐phase layer‐by‐layer encapsulation can be used to produce surface‐bound semipermeable microenclosures that can trap biomolecules. Biomolecules such as nucleic acids and proteins can be encapsulated whilst preserving their functionality. Electrophoresis can be used to create sharp concentration gradients, and enzymatic reactions such as DNA digestion can be controlled by diffusion of ions into the microenclosures (see picture).