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Diastereo‐ and Enantioselective Catalytic Tandem Michael Addition/Mannich Reaction: Access to Chiral Isoindolinones and Azetidines with Multiple Stereocenters
Author(s) -
Guo Shengmei,
Xie Yinjun,
Hu Xinquan,
Xia Chungu,
Huang Hanmin
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200907320
Subject(s) - stereocenter , enantioselective synthesis , michael reaction , mannich reaction , tandem , catalysis , chemistry , azetidine , combinatorial chemistry , stereochemistry , organic chemistry , materials science , composite material
Michael and Mannich cooperate : A rapid and reliable approach to highly functionalized chiral isoindolindone and azetidine derivatives, possessing multiple contiguous stereogenic centers, has been achieved (see scheme).