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General and Efficient Copper‐Catalyzed Three‐Component Coupling Reaction towards Imidazoheterocycles: One‐Pot Synthesis of Alpidem and Zolpidem
Author(s) -
Chernyak Natalia,
Gevorgyan Vladimir
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200907291
Subject(s) - zolpidem , imidazopyridine , component (thermodynamics) , computer science , information retrieval , combinatorial chemistry , chemistry , medicine , pharmacology , physics , thermodynamics , insomnia
Three is not a crowd : A method for the construction of imidazopyridine, imidazoquinoline, and imidazoisoquinoline frameworks has been developed. The synthetic utility of this method was demonstrated in a highly efficient one‐pot synthesis of the drugs alpidem and zolpidem (see scheme).