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Asymmetric Nazarov Reaction Catalyzed by Chiral Tris(oxazoline)/Copper(II)
Author(s) -
Cao Peng,
Deng Chao,
Zhou YouYun,
Sun XiuLi,
Zheng JunCheng,
Xie Zuowei,
Tang Yong
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200907266
Subject(s) - oxazoline , catalysis , copper , trifluoromethyl , chemistry , tris , enantioselective synthesis , boron , medicinal chemistry , combinatorial chemistry , polymer chemistry , organic chemistry , biochemistry , alkyl
Beverly Hills copper(II) : A highly efficient catalytic asymmetric Nazarov reaction has been developed through control of the enantioselectivity of the cyclization step, affording chiral O‐heterohexahydroindenones in excellent yields with excellent enantioselectivity and diastereoselectivity. HFIP=hexafluoro‐2‐propanol, B ArF = tetrakis[3,5‐bis(trifluoromethyl)phenyl] borate.