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Radical Synthesis of Guanidines from N ‐Acyl Cyanamides
Author(s) -
Larraufie MarieHélène,
Ollivier Cyril,
Fensterbank Louis,
Malacria Max,
Lacôte Emmanuel
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200907237
Subject(s) - cyanamide , guanidine , radical , chemistry , modular design , computer science , combinatorial chemistry , programming language , organic chemistry
Center stage : Additions of nitrogen‐centered radicals to cyanamide compounds provided the first radical synthesis of aromatic polycyclic guanidine derivatives (see scheme). Modular assembly of the substrates allows for a rapid increase of the molecular complexity of scaffolds, which have potential applications for medicinal chemistry.