Probing the Molecular Recognition of a DNA⋅RNA Hybrid Duplex | Zendy

Wheelhouse Richard T. | Zendy; Garbett Nichola C. | Zendy; Buurma Niklaas J. | Zendy; Chaires Jonathan B. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Probing the Molecular Recognition of a DNA⋅RNA Hybrid Duplex

Author(s) -

Wheelhouse Richard T.,

Garbett Nichola C.,

Buurma Niklaas J.,

Chaires Jonathan B.

Publication year - 2010

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200907235

Subject(s) - duplex (building) , dna , cyan , ligand (biochemistry) , base pair , chemistry , rna , crystallography , stereochemistry , biology , computational biology , gene , physics , biochemistry , receptor , optics

Curiouser and curiouser! A biarylpyrimidine ligand (see picture: N blue, H cyan, S yellow) shows a marked structure and sequence selectivity for the poly(dA)⋅poly(rU) hybrid duplex. An intercalative binding site was discovered where the ligand occupies a surprising ten base pairs. A strong correlation between hybrid duplex and DNA triplex binding indicates new directions for ligand design.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research