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Probing the Molecular Recognition of a DNA⋅RNA Hybrid Duplex
Author(s) -
Wheelhouse Richard T.,
Garbett Nichola C.,
Buurma Niklaas J.,
Chaires Jonathan B.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200907235
Subject(s) - duplex (building) , dna , cyan , ligand (biochemistry) , base pair , chemistry , rna , crystallography , stereochemistry , biology , computational biology , gene , physics , biochemistry , receptor , optics
Curiouser and curiouser! A biarylpyrimidine ligand (see picture: N blue, H cyan, S yellow) shows a marked structure and sequence selectivity for the poly(dA)⋅poly(rU) hybrid duplex. An intercalative binding site was discovered where the ligand occupies a surprising ten base pairs. A strong correlation between hybrid duplex and DNA triplex binding indicates new directions for ligand design.