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Enantioselective Symmetry Breaking Directed by the Order of Process Steps
Author(s) -
Noorduin Wim L.,
Meekes Hugo,
van Enckevort Willem J. P.,
Kaptein Bernard,
Kellogg Richard M.,
Vlieg Elias
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200907231
Subject(s) - enantioselective synthesis , racemization , enantiomer , order (exchange) , grinding , dissolution , computer science , chiral symmetry breaking , partially ordered set , process (computing) , symmetry breaking , chemistry , catalysis , stereochemistry , mathematics , combinatorics , organic chemistry , materials science , physics , particle physics , business , programming language , finance , composite material
Going forward in reverse : The configuration of the product of grinding‐induced symmetry breaking can be controlled simply by the order in which the different reaction‐mixture components are combined (see scheme: I) glass beads, II) racemic mixture (enantiomers differentiated by color), III) solvent, IV) racemization catalyst). The underlying mechanism is based on a subtle balance between enantioselective crystal growth and dissolution.