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A Tumor‐Acidity‐Activated Charge‐Conversional Nanogel as an Intelligent Vehicle for Promoted Tumoral‐Cell Uptake and Drug Delivery
Author(s) -
Du JinZhi,
Sun TianMeng,
Song WenJing,
Wu Juan,
Wang Jun
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200907210
Subject(s) - nanogel , intracellular , in vivo , extracellular , protonation , in vitro , drug , drug delivery , chemistry , biophysics , biochemistry , pharmacology , organic chemistry , biology , ion , microbiology and biotechnology
A positive (or negative) chameleon : A nanogel that is negatively charged at physiological pH values and activated to be positively charged at tumor extracellular pH values was internalized efficiently by tumor cells both in vitro and in vivo (see illustration). Intracellular drug release was also enhanced, probably as a result of a decrease in the interaction between the drug and the nanogel in its protonated state.