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Tunable Bromomagnesium Thiolate Tishchenko Reaction Catalysts: Intermolecular Aldehyde–Trifluoromethylketone Coupling
Author(s) -
Cronin Linda,
Mai Francesco,
O' Connor Cornelius J.,
Con Stephen J.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200907167
Subject(s) - steric effects , catalysis , aldehyde , intermolecular force , coupling reaction , chemistry , combinatorial chemistry , coupling (piping) , computational chemistry , organic chemistry , molecule , materials science , metallurgy
Applied knowledge : A new thiolate‐catalyzed Tishchenko reaction inspired by biochemical processes features exceptionally good control over the catalyst's steric/electronic properties. The isolation of reaction intermediates provided valuable insights into the reaction mechanism, which in turn has allowed the development of the first cross‐Tishchenko coupling reactions between aldehydes and activated ketones (see example).