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Pulling a Single Polymer Molecule off a Substrate Reveals the Binding Thermodynamics of Cosolutes
Author(s) -
Geisler Michael,
Netz Roland R.,
Hugel Thorsten
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200907098
Subject(s) - macromolecule , polymer , molecule , polymer science , chemistry , adsorption , organic chemistry , biochemistry
To bind or not to bind : Cosolutes modify, or even determine, the interactions between macromolecules and surfaces. A combination of single‐molecule atomic force microscopy with thermodynamic modeling allows the extraction of the binding parameters of cosolutes onto a macromolecule in solution and also in its surface‐adsorbed state.
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