Nanoparticles for Drug Delivery Prepared from Amphiphilic PLGA Zwitterionic Block Copolymers with Sharp Contrast in Polarity between Two Blocks | Zendy

Cao Zhiqiang | Zendy; Yu Qiuming | Zendy; Xue Hong | Zendy; Cheng Gang | Zendy; Jiang Shaoyi | Zendy

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Nanoparticles for Drug Delivery Prepared from Amphiphilic PLGA Zwitterionic Block Copolymers with Sharp Contrast in Polarity between Two Blocks

Author(s) -

Cao Zhiqiang,

Yu Qiuming,

Xue Hong,

Cheng Gang,

Jiang Shaoyi

Publication year - 2010

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200907079

Subject(s) - copolymer , amphiphile , nanoparticle , drug delivery , polarity (international relations) , contrast (vision) , chemistry , block (permutation group theory) , nanotechnology , materials science , polymer chemistry , chemical engineering , combinatorial chemistry , organic chemistry , computer science , polymer , geometry , mathematics , artificial intelligence , engineering , biochemistry , cell

In sharp contrast : Poly(carboxybetaine) (PCB)–poly(lactic‐co‐glycolic acid) (PLGA) block copolymers were obtained by inclusion of t Bu groups onto the PCB monomers. The resulting self‐assembled PLGA core/PCB shell nanoparticles have extraordinary stability and a high potential for functionalization because of the COO − groups on the PCB shell (see picture; EDC=1‐ethyl‐3‐(3‐dimethylaminopropyl)carbodiimide; NHS= N ‐hydroxysuccinimide).

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