Premium
Nanoparticles for Drug Delivery Prepared from Amphiphilic PLGA Zwitterionic Block Copolymers with Sharp Contrast in Polarity between Two Blocks
Author(s) -
Cao Zhiqiang,
Yu Qiuming,
Xue Hong,
Cheng Gang,
Jiang Shaoyi
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200907079
Subject(s) - copolymer , amphiphile , nanoparticle , drug delivery , polarity (international relations) , contrast (vision) , chemistry , block (permutation group theory) , nanotechnology , materials science , polymer chemistry , chemical engineering , combinatorial chemistry , organic chemistry , computer science , polymer , geometry , mathematics , artificial intelligence , engineering , biochemistry , cell
In sharp contrast : Poly(carboxybetaine) (PCB)–poly(lactic‐co‐glycolic acid) (PLGA) block copolymers were obtained by inclusion of t Bu groups onto the PCB monomers. The resulting self‐assembled PLGA core/PCB shell nanoparticles have extraordinary stability and a high potential for functionalization because of the COO − groups on the PCB shell (see picture; EDC=1‐ethyl‐3‐(3‐dimethylaminopropyl)carbodiimide; NHS= N ‐hydroxysuccinimide).