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Direct Synthesis of Imines from Alcohols and Amines with Liberation of H 2
Author(s) -
Gnanaprakasam Boopathy,
Zhang Jing,
Milstein David
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200907018
Subject(s) - pincer movement , chemistry , toluene , inert gas , ruthenium , isopropyl , organic chemistry , atmosphere (unit) , catalysis , liberation , hydrogen , polymer chemistry , aryl , biochemistry , physics , alkyl , in vitro , thermodynamics
A clean sweep : Aryl and aliphatic imines can be synthesized directly and efficiently from alcohols and amines under mild, neutral conditions with the liberation of only molecular hydrogen and water (see scheme; R=isopropyl, tert ‐butyl). This general, environmentally benign reaction is catalyzed by a de‐aromatized ruthenium PNP pincer complex (0.2 mol %), and can proceed in toluene under an inert atmosphere or under air.