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Direct Synthesis of 1,4‐Disubstituted‐5‐alumino‐1,2,3‐triazoles: Copper‐Catalyzed Cycloaddition of Organic Azides and Mixed Aluminum Acetylides
Author(s) -
Zhou Yuhan,
Lecourt Thomas,
Micouin Laurent
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200907016
Subject(s) - cycloaddition , regioselectivity , electrophile , aluminium , copper , chemistry , catalysis , organic synthesis , combinatorial chemistry , organic chemistry
Al together now : Aluminotriazoles are obtained in a fully chemo‐ and regioselective manner by a copper‐catalyzed cycloaddition of organic azides with mixed‐aluminum acetylides (see scheme). The carbonaluminum bond, which is unaffected by the first transformation, is still able to react further with different electrophiles.