Decarboxylative CH Cross‐Coupling of Azoles | Zendy

Zhang Fengzhi | Zendy; Greaney Michael F. | Zendy

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Decarboxylative CH Cross‐Coupling of Azoles

Author(s) -

Zhang Fengzhi,

Greaney Michael F.

Publication year - 2010

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200906921

Subject(s) - azole , chemistry , catalysis , molecular sieve , combinatorial chemistry , dimethyl sulfoxide , palladium , sulfoxide , coupling reaction , copper , organic chemistry , medicinal chemistry , antifungal , medicine , dermatology

Côte d'Azole : The title reaction demonstrates the use of diverse oxazoles 2 as suitable substrates in cross‐coupling reactions with azole‐5‐carboxylic acids 1 under palladium catalysis in the presence of copper carbonate. The reaction is successful for the synthesis of a range of bis(azole)s, and has been applied to the convergent synthesis of challenging poly azoles (dcpe=bis(dicyclohexylphosphino)ethane, DMSO=dimethyl sulfoxide, M.S.=molecular sieves).

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