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An Aptamer Targeting the Apical‐Loop Domain Modulates pri‐miRNA Processing
Author(s) -
Lünse Christina E.,
Michlewski Gracjan,
Hopp Christine S.,
Rentmeister Andrea,
Cáceres Javier F.,
Famulok Michael,
Mayer Günter
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200906919
Subject(s) - aptamer , microrna , rna , computational biology , microbiology and biotechnology , biology , rna interference , gene , genetics
Gaining maturity : RNA aptamers can serve as specific targeting molecules to modulate the processing of pri‐miRNAs. This approach can be used to selectively interfere with microRNA regulation and may open new routes for the development of novel therapies.