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Iron‐Catalyzed Direct Arylation of Unactivated Arenes with Aryl Halides
Author(s) -
Liu Wei,
Cao Hao,
Lei Aiwen
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200906870
Subject(s) - halide , aryl , catalysis , ligand (biochemistry) , chemistry , base (topology) , diamine , medicinal chemistry , organic chemistry , combinatorial chemistry , polymer chemistry , mathematics , alkyl , receptor , mathematical analysis , biochemistry
Iron tough : Various aryl halides were treated with unactivated arenes to form biaryl compounds in moderate to good yields. The reactions were carried out at relatively low temperature in the presence of a catalytic amount of FeCl 3 , with DMEDA as the ligand and LiHMDS as the base (see scheme; DMEDA= N,N ' ‐dimethylethane‐1,2‐diamine, HDMS=hexamethyldisilazanide).
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