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Multinuclear Catalyst for Copper‐Catalyzed Asymmetric Conjugate Addition of Organozinc Reagents
Author(s) -
Endo Kohei,
Ogawa Mika,
Shibata Takanori
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200906839
Subject(s) - conjugate , catalysis , reagent , copper , combinatorial chemistry , ligand (biochemistry) , enantioselective synthesis , chemistry , metal , computer science , organic chemistry , mathematics , biochemistry , mathematical analysis , receptor
A whole lot o' metal : An efficient copper‐catalyzed asymmetric conjugate addition was achieved using a binol‐derived ligand. The catalytic system has a turnover number of 2000, and the excellent catalytic performance could be attributed to the generation of a multinuclear complex such as 1 . binol=2,2′‐dihydroxy‐1,1′‐binaphthyl.