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Fragmentation Enables Complexity in the First Total Synthesis of Vinigrol
Author(s) -
Lu JinYong,
Hall Dennis G.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200906826
Subject(s) - stereocenter , fragmentation (computing) , intramolecular force , total synthesis , stereochemistry , chemistry , computer science , enantioselective synthesis , organic chemistry , catalysis , operating system
Vinigrol at last : A unique tricyclic framework and eight contiguous stereogenic centers have made vinigrol a challenging but highly prized target for the synthetic community. The first total synthesis of vinigrol was recently completed by Baran and co‐workers using an intramolecular Diels–Alder reaction, a Grob fragmentation, and a series of creative endgame functionalization reactions.
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